Besides glyoxalase 1, among numerous targets of the Nrf2 transcription factor are both antioxidant and antiglycation enzymes: superoxide dismutase, catalase, glutathione peroxidase, peroxiredoxin, thioredoxin reductase, -glutamylcysteine synthase, glutathione reductase, thioredoxine reductase, glutathione S-transferases, glutathione reductase (2, 8)
Patient overlap: In a clinical setting, these tools are not either/or
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Those given the glutathione not only had fewer side effects from the chemotherapy but also had better overall survival rates
Typically administered through injections, this antioxidant-based therapy works by reducing melanin levels the pigment responsible for dark spots and uneven skin tone